Describe Is RBC(Red Blood Corpuscles)

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RBC(Red Blood Corpuscles):-

Red blood corpuscles are oval, binconvex and nucleated in vertebrates form fishes to birds and in  mammals like camel and llama. In all other mammals, the red blood corpuscles are circular, biconcave and enucleated they are nucleated during their initial stages of development but later on along with nucleus other cell organelles like mitochondria, endoplasmic reticulum, Golgi body and ribosome etc. also disappear biconcave shape increase the surface area while absence of organelles provide extra space to accommodate haemoglobin.

Describe is RBC

Human red blood corpuscle measures 7.2 to 7.5μ in diameter and 2.2μ in thickness and have an average volume  of 88-90 μ³. There are about 5 million/mm³ of RBCs in the blood of an adult human male. In human females their number is about 4.5 million/mm³.

During foetal stage red blood corpuscles are produced in the liver and spleen but after the birth this funcation is taken over by red bone. marrow of long bones. Their production is controlled by a hormone Erythropoeitin secreted by kidney. Process of their production is termed as erythropoeisis while the organ where they are produced are called erythropoietic organs. The cell which produce erythropoietic are called erythroclasts. The maturation of red blood. corpuscles is controlled by folic acid and vitaminB12

, therefore lack of these vitamins causes anaemia. Deficiency of vitamin B12 causes pernicious or megaloblastic anaemia. Red blood cells present in excess are stored in spleen, hence,it is called blood bank of the body.

Red blood corpuscles have a life span of 120 days. The dead and worn out RBCs are destroyed by reticuloendothelial cells of bone marrow, liver and spleen. The iron of the haemoglobin released in this process is separated form the haem. Pigment bilirubin is also formed from haemoglobin and released in intestine with bile. Later on it is converted into stercobilin and urobilin and excreted with faces and urine. In human being about 8 gm haemoglobin is converted into bile pigment in 24 hours.

The release of haemoglobin from the damaged cell membrane of red blood corpuscle is called haemolysis . Red blood cells devoid of haemoglobin are called Shadow or Phantom Corpuscles(Ghost RBCs)