Anti Asthmatic drugs and classification

Anti Asthmatic drugs and classification

Anti Asthmatic drugs and classification :- Anti-Asthmatic drug are used for the treatment  of asthma.

Classification

A. Bronchodilators

1. Sympathomimetics
2. Methylxanthines
3. Anticholinergics
  • Atropine mrthonitrate
  • Ipratropium bromide
  • Tiotropium bromide

B. Leukotriene antagonists

  1. Montelukast
  2. Zafirlukast

C. Mast cell stabilizers

  1. Sodium eromaglycate
  2. nedocromil, ketotifen

D. Croticosteroids

  1. Systemic
  • Hydrocortisone
  • Prednisolone and others
2. Inhalational
  • Beclomethasone
  • Dipropionate
  • Budenlonide

Bronchodilators

Bronchodilators when given by appropriate route, relive symptoms of asthma and improve breathing. They cause the relexation of the brochial smooth muscles and improve pulmonary function.

Sympathomimetics

  • Adrenaline

It i sthe patent drugs which acts by stimulating beta receptors in the brochial smooth muscles. It relivees an acute attack and also relives pulmonary congestion by constricting pulmonary arteries.

prolonged use of adrenaline in brochial asthma may produce resistance also it produce side effect like venticular tachycardia and venticular fibrollation.

Adrenaline should not be give in patient with cardiac asthma, hypertension and hyperthyroidism.

Dose :– 0.2 to 0.5 ml of 1 in 1000 solution adminstration by subcutaneous injection.

  • Isoprenaline

It acts on beta receptors of bronchi. It is adminstered sublingually at dose of 10 to 20 mg.

Pharmacological Action

  1. CNS
  2. CVS
  3. Smooth muscles
  4. Kidney
  5. Skkeletal muscles
  6. Anticholinergics

Leukotriene antagonists

An leukotrine antagonists is a drug which function as a leukotriene related enzyme inhibitor or leukotriene receptor antagonist and conseently opposes the function of these inflammatory mediators leukotrienes are produced by the immune system.

Leukotriene receptor antagonists such as montelukast, Zafirlukast can be used to treat there disease.

They are less effect than corticosteroids for treating asthma but more effecive for treating certain mast cell disoders.

MOA (Mode of Action)

Montelucast, zafirlukast ae competively prevent the bronhcoconstrictor effects of leukotrienes.

  • By blocking there receptor
  • Prevent leeukotriene from attaching to receptor on cell in the lungs and in circulation.
  • Blocking the inflammationin the lungs.

Side Effect

  • Headache
  • Stomach pain
  • heartburn
  • Upset stomach
  • Nausea
  • Diarrehea
  • tooth pain
  • Trideness
  • Fever, sore throat, cough
  • Mild rash.

Use 

Prophylaxis and chronic treatment of assthma.